Scruffy (voiced by Nancy McKeon) is a lovable puppy struggling to survive in an unfamiliar world where she loses loved ones, battles fiendish foes and learns the value of loyal friends.

Scruffy – frightened and freezing – returns alone to the big city and finds an affectionate new master, a ragged but regal Shakespearean street performer named Tibbles (voiced by Hans Conried).

Scruffy meets a tough bulldog named Butch (voiced by Michael Bell) who takes her to join his family of strays who have set up a canine commune in an abandoned station wagon.