Denver's busiest vet is back, with more patients than ever before. Dr. Jeff fights to help a dog walk again. Dr. Amy operates on a cat with a strange appetite. And the team heads out to a sanctuary to help an injured tiger.

Dr. Jeff operates on a dog rushed to the clinic after a growth on her neck ruptures. A family brings in their rabbit with mysterious growths on her side. And the team performs a risky procedure on a pair of rescued miniature donkeys.

An owner drives nine hours to the clinic hoping Dr. Jeff can save her dog's leg. Jeff and his team head to a wildlife sanctuary to treat a pack of wolves. And when a kitten with a deformed leg needs treatment, Dr. Baier steps up to the plate.

Two sisters rush their dog to the clinic with a life-threatening brain injury. Dr. Jeff is perplexed by a dog with a broken jaw. A fearless cat with a broken leg wins the admiration of the clinic staff. And the team treats some uncooperative yaks.

Dr. Jeff battles to fix a German shepherd's broken elbow and get him back to his worried owner, a disabled war veteran; a cat with a swollen bladder needs difficult surgery to save its life; Drs. Baier and Hector head to an exotic bird sanctuary.

Dr. Jeff must act fast to save a bulldog after a life-threatening accident; when devastating floods hit Louisiana, Dr. Jeff sends vet tech Hector to rescue pets left homeless in the disaster; Dr. Don operates on a cat with a bad habit.