Actor David Arquette (The Female of the Species), actress Abbie Cornish (Bright Star), stand up comedian Jim Breuer

Actor Neil Patrick Harris (How I Met Your Mother), actor Jeremy Renner (The Hurt Locker), musical guest Really Doe.

Actress Ellen Pompeo (Grey's Anatomy), NFL analyst Michael Strahan (Brothers, "NFL Sunday"), musical guest Puddle of Mudd

Actor Tobey Maguire (Brothers), actress Shenae Grimes (90210), musical guest Colbie Caillat performs "I Never Told You"

Jimmy as "Jay Leno" hosts. Actor Chevy Chase (Community), actress Elisha Cuthbert (The Forgotten and 24), musical guest Melanie Fiona performs "It Kills Me"

Jimmy spoke with actress Kate Walsh (Legion and Private Practice) about turtles and speaking Spanish, and actor Aziz Ansari (Aziz Ansari: Intimate Moments for a Sensual Evening and Parks and Rec) about his breakthrough year on television and his fascination with R. Kelly. Also, musical guests Larry Gatlin and the Gatlin Brothers performed "Johnny Cash is Dead." But first, Jimmy says goodbye to Michael Jackson's giraffes, J.J. and Rambo, who died, and we get a special peek into Guillermo's scandal on The Bachelor.

Actress Evangeline Lilly (Lost), Miss South Carolina Teen USA 2007 Caite Upton, musical guest Katharine McPhee

Actor Dax Shepard (When in Rome), personality Joan Rivers, chef Paul Bartolotta

Actor Dennis Quaid (Legion), actor Ty Burrell (Modern Family), musical guest Orianthi

Actor Paul Bettany (Legion), The Bachelor Jake Pavelka, musical guest Pearl

Actor Dwayne Johnson (Tooth Fairy), Duane "Dog" Chapman (Dog the Bounty Hunter), stand-up comedian Dwayne Kennedy

Actress Cheryl Hines (Brothers & Sisters), actor Jared Harris (Extraordinary Measures), musical guest Heartless Bastards

Actor Harrison Ford (Extraordinary Measures), actress Kristin Bell (When in Rome), musical guest Silversun Pickups

Actor Mel Gibson (Edge of Darkness), actress Kate Micucci (When in Rome), musical guest Mayer Hawthorne

Actor Will Arnett (When in Rome), actress Kim Raver (Grey's Anatomy), musical guest Slightly Stoopid

Jimmy spoke with actor Josh Duhamel (When in Rome) about doing his own stunts, and Shorty Rossi (Animal Planet's Pit Boss) about his pit bulls and dating tall women. And musical guest John Mayer performed "Heartbreak Warfare." But first, Jimmy led the audience in pledging their lives to Oprah for her birthday, and Guillermo broke the news to Jimmy about a nationwide salami recall. Also, it's Friday, which meant another installment of This Week in Unnecessary Censorship

Tennis champion Serena Williams, Damon Lindelof and Carlton Cuse (writers of Lost), musical guest Lady Antebellum

Jimmy interviewed Dr. Phil McGraw (Dr. Phil) and musician Nick Jonas (Nick Jonas and the Administration), and stand-up comedian Demetri Martin performed.

Jimmy spoke with actor Eric Dane (Valentine's Day and Grey's Anatomy) and celebrity Kourtney Kardashian. Musical guest The Bravery performed "Hateful." But first, Jimmy's natural comedic ability in working with children shined as he dressed as a pig and talked to two young boys. After having a brief chat on how hard it is to be a fat pig, Jimmy convinced the boys to give him water even though they were told not to. Jimmy then peed all over Cowboy Cousin Sal.

Jimmy interviews Ozzy Osbourne (I Am Ozzy) and Barry Manilow; Barry Manilow performs

Oscar nominee Maggie Gyllenhaal (Crazy Heart), animal specialist Dave Salmoni, musical guest Ryan Bingham

Actress Emily Blunt (The Wolfman), actor J.B. Smoove (Curb Your Enthusiasm), musical guest Editors

Actor Patrick Dempsey (Valentine's Day and Grey's Anatomy), actress Lake Bell (How to Make it in America), stand-up comedian Greg Giraldo (Midlife Vices)

Actor Mark Wahlberg (How to Make it in America), Sports Illustrated Swimsuit Issue cover model Brooklyn Decker, musical guest Dashboard Confessional

Jimmy spoke with actor Michael Emerson (LOST) and host Camila Alves (Shear Genius), plus musical guest Sade performed her #1 hit "Soldier of Love"

Actor Tracy Morgan (Cop Out), interview with musical guest Brad Paisley

Jimmy spoke with actor Freddie Prinze Jr. (24) and professional race car driver Danica Patrick, and musical guest Robin Thicke performed "Sex Therapy".

Actor Shia LaBeouf (Wall Street: Money Never Sleeps), reality personality/writer Lauren Conrad (Sweet Little Lies), musical guest Wale

Jimmy spoke with actor David Spade and sat down with The Trailer Park Boys: Rob Wells, Mike Smith, and John Paul Tremblay. Then musical guest Miss Willie Brown performed "Rodeo Queen" and "Bonafied" in their network television debut.

Jimmy spoke with Andy Garcia (City Island) and pageant director Michael Galanes (Little Miss Perfect), plus stand up comedian Dana Gould performed.

Jimmy spoke with chef/host Gordon Ramsay (Kitchen Nightmares) and actress Ginnifer Goodwin (Big Love), and musical guest VV Brown performed "Shark in the Water."

Actress Dana Delany (Desperate Housewives), Olympic snowboarder Scotty Lago, musical guest Daniel Merriweather

SECRET GUESTS! Kate Gosselin, new "Dancing with the Stars" cast member; the next "Bachelorette," Ali Fedotowsky; musical guest Josh Turner.

Jimmy spoke with actress Anne Hathaway (Alice in Wonderland) and actor Jesse Williams (Brooklyn's Finest). But, yum, Chef Tom Colicchio (Top Chef) served up some serious dish.

Actor Ethan Hawke (Brooklyn's Finest), boxer Manny Pacquiao (World Welterweight Championship), musical guest Jet

Queen Latifah, “Bachelor” Jake Pavelka & Vienna Girardi, Galactic with Allen Toussaint

On a historic night where Jimmy Kimmel has previously debuted such pieces as the I'm F@#%-ing Ben Affleck music video and Mel Gibson's The Colonel, he introduced a new star-studded video including Jimmy and 15 of the most handsome men in Hollywood who come together for the handsomest gathering ever. Jimmy also welcomed two-time Academy Award® nominee Robert Downey Jr. who presented the world premiere of the new Iron Man 2 trailer, and a musical performance by Grammy Award® winner Keith Urban. Plus special appearances by Ben Affleck, Jennifer Garner, Matthew McConaughey, Patrick Dempsey, Sting, and many more.

Robin Wright, Jason Mesnick & Molly Malaney (The Bachelor: Jason & Molly's Wedding), and a music performance by Corinne Bailey Rae

Gabourey Sidibe (Oscar nominated star of Precious), actor Josh Hopkins (Cougar Town), musical performance by Gary Allan

Academy Award winner Christoph Waltz (Inglourious Basterds), Tom Papa (The Marriage Ref), musical guest Manchester Orchestra

TV personality Nicole Richie, and a musical performance by Gin

Actress Demi Lovato (Sonny With A Chance), Tom Bergeron (host of Dancing w/the Stars), musical guest The All-American Rejects.

Actor Scott Wolf (V), actor Clark Duke (Hot Tub Time Machine), musical guest Neon Trees.

Actor Gerard Butler (Bounty Hunter), actress Gabrielle Union (FlashForward), musical guest Jamie Cullum.

Actor Pierce Brosnan (The Greatest), actor Craig Robinson (Hot Tub Time Machine and The Office), music from Sarah McLachlan with Emmylou Harris.

Actress Elizabeth Mitchell (V and Lost), actor Liam Hemsworth, stand-up comedy from Kevin Nealon.

Miley Cyrus, Bruno Tolioni (Dancing with the Stars), musical guest Erykah Badu performs.

Tom Arnold, actress Greta Gerwig (Greenberg), musical guest Matisyahu.

Actress Carey Mulligan (The Greatest), Eva Longoria Parker (Desperate Housewives), musical guest OK GO.

Jimmy spent the evening with Twilight's "Emmett Cullen" Kellan Lutz (Nightmare on Elm Street) and Dancing with the Stars co-host (and former champion) Brooke Burke, and She & Him performed "Thieves" on the lobby stage.

NBA star Kobe Bryant, latest celebrity eliminated from Dancing w/the Stars, musical guest Kelis.

Luke Wilson (Death at a Funeral), Aaron Johnson (Kick-Ass), musical guest PiL.

Martin Lawrence (Death at a Funeral), a demo from "Science Bob" Pflugfelder, musical guest Jonathan Tyler & the Northern Lights.

Pamela Anderson (Dancing with the Stars), Nathan Fillion (Castle), musical guests Them Crooked Vultures.

Zoe Saldana, Balthazar Getty (Brothers & Sisters), Aiden Turner (eliminated from DWTS), Them Crooked Vultures perform a second night.

Actress Alyssa Milano (Romantically Challenged), producer Jerry Weintraub, musical guest Gloriana.

David Duchovny, "McLovin" Christopher Mintz-Plasse, Spoon performs.

Tim Allen, Alex O'Loughlin, Cypress Hill featuring Tom Morello

Actress Jenna Elfman (Accidentally on Purpose), latest celebrity eliminated from Dancing With The Stars, musical guest DEVO

Actor/Rapper Ice Cube (Straight out of LA on ESPN), cooking demo with Chef Paula Deen, musical guest Rob Zombie.

Actor Chace Crawford ("Gossip Girl"), actor Anthony Anderson ("The Back-up Plan"), musical guest Taylor Hawkins

Megan Mullally, Erin Andrews, National School Scrabble 2010 Winners Evan McCarthy & Bradley Robbins

Dominic Monaghan, the latest "Dancing With The Stars" castoff, Civil Twilight

Julie Bowen, Craig Robinson, Dr. Dog

Courtney Love, boxing rabbi Yuri Foreman, Hole

Dr. Mehmet Oz, Two Door Cinema Club

Actor Mickey Rourke; Jorge Garcia; the latest "Dancing with the Stars" castoff, Pamela Anderson.

Samuel L. Jackson, Christa Miller, Godsmack.

Daniel Dae Kim, Angels & Airwaves

Don Cheadle, Geoff Stults, Crash Kings

Actress Julia Louis-Dreyfus; the latest "Dancing with the Stars" castoffs, Niecy Nash & Louis Van Amstel; musical guest Michael Bolton.

Dr. Phil McGraw, Landon Donovan, B.o.B.

Ryan Phillippe, Beth Ostrosky Stern, Dirty Heads.

Michael Douglas, Atticus Shaffer, Reflection Eternal featuring Estelle.

Josh Holloway, Adam Perry Lang, Slayer.

Teri Hatcher, Damon Lindelof and Carlton Cuse (LOST), Massive Attack.

LOST stars Matthew Fox (Jack), Terry O'Quinn (Locke), Michael Emerson (Ben), Naveen Andrews (Sayid), Emilie de Ravin (Claire), Daniel Dae Kim (Jin), Jorge Garcia (Hurley), Josh Holloway (Sawyer), Evangeline Lilly (Kate) and more, plus alternate endings

Adrien Brody, "The Bachelorette" Ali Fedotowsky, Damian Marley and Nas.

Jake Gyllenhaal, the winner of "Dancing with the Stars", Peter Frampton

This year's NBA Finals winner L.A. Lakers (Ron Artest, Shannon Brown, Kobe Bryant, Derek Fisher, D.J. Mbenga, Josh Powell and Sasha Vujacic); musical guests The Specials.

After a power failure knocks out the studio cameras, lighting, microphones and editing equipment, Jimmy Kimmel broadcasts his entire show from his laptop, featuring chats with audience members and an acoustic performance from Dierks Bentley and his backup musicians.

The cast of “The Twilight Saga: Eclipse,” including Robert Pattinson, Kristen Stewart, Taylor Lautner, Dakota Fanning, Bryce Dallas Howard and Xavier Samuel. The third film in the “Twilight” series opens June 30

Dakota Fanning, grocery list collector Bill Keaggy, KoRn.

Kyra Sedgwick, Jay Baruchel, N.E.R.D

Jon Hamm, J.B. Smoove, Ralph Macchio, Runner Runner.

Adam Carolla, 5-year-old baseball phenomenon Ariel Antigua, Raheem DeVaughn

The cast of "Modern Family", Julie Bowen, Ty Burrell, Eric Stonestreet & Jesse Tyler Ferguson; the latest "Dancing with the Stars" castoff, David Hasselhoff; musical guests Band of Horses.